|| Head of Laboratory
|| Research field
|Central Nervous System Physiology
||Study of the mechanisms of functional organization and plasticity of the brain motor structure.
|Central Nervous System functions compensation Physiology
||John S. Sarkissian
||Plasticity of morphofunctional organization and reorganization of the CNS under conditions of protective impact of biomodulators in cases of acute and chronic nuerodegeneration of specific and nonspecific origin.
|Immunology and Tissue Engineering
||Generate immuno-compatible differentiated stem cells and to prove that these cells are capable of re-populating de-cellularized scaffolds. Second is to generate an assortment of mesenchymal stem cells from non-related individuals that can be turned into many solid organ tissues and be compatible with a large percent of human population.
|Physiology of Autonomic Nervous System
||Neuronal organization of the central regulating mechanisms of the autonomic functions. Cortical and subcortical mechanisms of integration of the visceral systems.
|Smooth Muscle Physiology
||Our research aims to understand the nature of spontaneous activities of smooth-muscle tissues, in particularly, the ureter’s and uterine activities. The existence of latent rithmogenic cells along with the main active pacemakers was shown. Coordination mechanisms of activities from different areas, which are providing peristaltic activity of entire organs, are studied.
|Toxinology and Molecular Systematics
||Studying the structure-functional properties of animals’ and plants’ venom peptides for designing novel therapeutic agents.
||1.Problems of CNS plasticity: Electrophysiological, biochemical, neurohistochemical and molecular mechanisms of different nonspecific (vestibular injury) and specific (Alzhemer’s and Parkinson’s diseases) neurodegenerative disorders. Synaptic mechanisms of different biomodulators’ neuroprotective effects upon vestibular compensation
2. Sport Physiology: investigations directed to development of methods of exercise physiology and problems of physical education, as well as systematic approach and integrated training programs.
|Histochemistry and Electromicroscopy
||Development of the new methods, providing wide opportunities to study histochemical and morpho-functional state of cellular structures of the brain and other tissues of the organism in norm and pathology.
||Investigation of short-term fluctuations of human brain functional activity.
||The basic direction of activity is connected with the search of alternative methods of estimation of integrative state of biological systems. Now the hardware complex “Bioscope” is developed which allows the remote investigation of an orientation of influences of external factors with various modality on a integral state of the awake organism.
|Purification, Certification and Standardization of physiologically active substances
||Investigation of mechanisms of venoms influence on CNS and BHS, R&D of nonspecific antitoxic remedies against hemorrhagic venoms. Venoms certification and development of new express methods of venoms identification.
||Synaptic activity of neuronal networks involved in memory processes in neurodegeneration induced by bilateral ovariectomy. Microelectrophysiological methods were used to assess the effectiveness of synthetic estrogen hormone replacement therapy and medicinal plant extracts.